Fzr1^tm1.1Yhou
Targeted Allele Detail

Summary

• Symbol: Fzr1^tm1.1Yhou
• Name: fizzy and cell division cycle 20 related 1; targeted mutation 1.1, Yu Hou
• MGI ID: MGI:7446457
• Synonyms: Fzr1^fl
• Gene: Fzr1 Location: Chr10:81202713-81214204 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Fzr1^tm1.1Yhou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321560
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 2 to 14 were flanked by loxP sites. The neomycin resistance gene flanked by rox sites that was inserted downstream of exon 14 before the second loxP site was removed. (J:321560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fzr1 Mutation: 43 strains or lines available

References

• Original: J:321560 Zhou C, et al., Insufficiency of FZR1 disturbs HSC quiescence by inhibiting ubiquitin-dependent degradation of RUNX1 in aplastic anemia. Leukemia. 2022 Mar;36(3):834-846
• All: 1 reference(s)