Nudt1^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Nudt1^tm1.1Nju
• Name: nudix hydrolase 1; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:7446373
• Synonyms: MTH1^fl
• Gene: Nudt1 Location: Chr5:140307411-140323892 bp, + strand Genetic Position: Chr5, 78.94 cM, cytoband G1
• Alliance: Nudt1^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332985
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector floxed exon 3. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:332985)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nudt1 Mutation: 31 strains or lines available

References

• Original: J:332985 Li J, et al., MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3. Free Radic Biol Med. 2022 Aug 1;188:447-458
• All: 2 reference(s)