Glp1r^{tm1d(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Glp1r^{tm1d(KOMP)Mbp}
• Name: glucagon-like peptide 1 receptor; targeted mutation 1d, Mouse Biology Program, UC Davis
• MGI ID: MGI:7446267
• Synonyms: Glp1r^-
• Gene: Glp1r Location: Chr17:31120841-31155484 bp, + strand Genetic Position: Chr17, 15.8 cM
• Alliance: Glp1r^{tm1d(KOMP)Mbp} page
• IMPC: Glp1r gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287072
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 31137266 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 31138983. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:287072)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glp1r Mutation: 52 strains or lines available

References

• Original: J:287072 Balk-Moller E, et al., Glucagon-Like Peptide 1 and Atrial Natriuretic Peptide in a Female Mouse Model of Obstructive Pulmonary Disease. J Endocr Soc. 2020 Jan 1;4(1):bvz034
• All: 3 reference(s)