Gt(ROSA)26Sor^{tm12(CAG-ZsGreen,-tdTomato)Bzsh}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm12(CAG-ZsGreen,-tdTomato)Bzsh}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 12, Bin Zhou
• MGI ID: MGI:7444933
• Synonyms: R26-NLR
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm12(CAG-ZsGreen,-tdTomato)Bzsh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266564
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A CAG-nox-loxP-Stop-nox-ZsGreen-polyA-loxP-tdTomato-wpre-Frt-Neo-Frt into intron 1 of Rose26 locus through homologous recombination. It is a Nigri/nox and Cre/loxP dual reporter. With Nigri recombinase activity, the STOP sequence is excised and ZsGreen can be expressed. With Cre recombinase activity, the STOP and ZsGreen sequences are removed allowing the expression of tdTomato downstream. (J:266564)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1096 strains or lines available

References

• Original: J:266564 Liu K, et al., A dual genetic tracing system identifies diverse and dynamic origins of cardiac valve mesenchyme. Development. 2018 Sep 17;145(18):dev167775
• All: 2 reference(s)