About   Help   FAQ
Ncor2tm1.1Mafa
Targeted Allele Detail
Summary
Symbol: Ncor2tm1.1Mafa
Name: nuclear receptor co-repressor 2; targeted mutation 1.1, Michael A Farrar
MGI ID: MGI:7444818
Synonyms: Ncor2FL
Gene: Ncor2  Location: Chr5:125094217-125256283 bp, - strand  Genetic Position: Chr5, 63.96 cM, cytoband F
Alliance: Ncor2tm1.1Mafa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:333184
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting construct inserted into intron 1 an FRT site, F3 site, loxP site, lox511, splice acceptor, beta-galactosidase gene, polyadenylation sequence, loxP site, lox511 site, FRT site, and F3 site. Flp-mediated recombination inverted the cassette allowing for normal gene splicing until crossed with a cre recombinase expressing gene. (J:333184)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncor2 Mutation:  170 strains or lines available
References
Original:  J:333184 Lee RD, et al., Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation. Nat Immunol. 2022 Dec;23(12):1763-1776
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/18/2025
MGI 6.24
The Jackson Laboratory