Ncor2^tm1.1Mafa
Targeted Allele Detail

Summary

• Symbol: Ncor2^tm1.1Mafa
• Name: nuclear receptor co-repressor 2; targeted mutation 1.1, Michael A Farrar
• MGI ID: MGI:7444818
• Synonyms: Ncor2^FL
• Gene: Ncor2 Location: Chr5:125094217-125256283 bp, - strand Genetic Position: Chr5, 63.96 cM, cytoband F
• Alliance: Ncor2^tm1.1Mafa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333184
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted into intron 1 an FRT site, F3 site, loxP site, lox511, splice acceptor, beta-galactosidase gene, polyadenylation sequence, loxP site, lox511 site, FRT site, and F3 site. Flp-mediated recombination inverted the cassette allowing for normal gene splicing until crossed with a cre recombinase expressing gene. (J:333184)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncor2 Mutation: 170 strains or lines available

References

• Original: J:333184 Lee RD, et al., Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation. Nat Immunol. 2022 Dec;23(12):1763-1776
• All: 2 reference(s)