Srebf1em1Hshim
Endonuclease-mediated Allele Detail
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Symbol: |
Srebf1em1Hshim |
Name: |
sterol regulatory element binding transcription factor 1; endonuclease-mediated mutation 1, Hitoshi Shimano |
MGI ID: |
MGI:7444486 |
Synonyms: |
SREBP-1a flox |
Gene: |
Srebf1 Location: Chr11:60089915-60113407 bp, - strand Genetic Position: Chr11, 37.81 cM
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Alliance: |
Srebf1em1Hshim page
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Allele Type: |
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Endonuclease-mediated (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: CRISPR-targeting floxed exon 1a. This conditional allele prevents expression of the a isoform when combined with a cre recombinase.
(J:333931)
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Inheritance: |
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Not Specified |
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Srebf1 Mutation: |
55 strains or lines available
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Original: |
J:333931 Araki M, et al., Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol. 2022 Dec 1;323(6):G627-G639 |
All: |
1 reference(s) |
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