Irak4^tm1.1Khli
Targeted Allele Detail

Summary

• Symbol: Irak4^tm1.1Khli
• Name: interleukin-1 receptor-associated kinase 4; targeted mutation 1.1, Kian-Huat Lim
• MGI ID: MGI:7442684
• Synonyms: IRAK4^f
• Gene: Irak4 Location: Chr15:94441495-94466198 bp, + strand Genetic Position: Chr15, 48.55 cM, cytoband F1
• Alliance: Irak4^tm1.1Khli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333404
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: InGenious TruView Conditional Knockout System was used to generate this conditional allele. Exons 2 to 12 were flanked by loxP sites and split green fluorescent protein (GFP) cassettes. The FRT-flanked neomycin selection cassette was removed at the embryonic stem cell stage via inGenious proprietary FLP embryonic stem cells. Upon cre-mediated recombination and deletion of the targeted region, the two GFP cassettes come together and express under the CAG promoter on the antisense strand. (J:333404)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irak4 Mutation: 33 strains or lines available

References

• Original: J:333404 Somani VK, et al., IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2022 Jun;162(7):2047-2062
• All: 1 reference(s)