Ago2^tm1Bcgen
Targeted Allele Detail

Summary

• Symbol: Ago2^tm1Bcgen
• Name: argonaute RISC catalytic subunit 2; targeted mutation 1, Biocytogen LLC
• MGI ID: MGI:7442640
• Gene: Ago2 Location: Chr15:72967693-73056777 bp, - strand Genetic Position: Chr15, 33.92 cM
• Alliance: Ago2^tm1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314308
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Epitope tag)
• Mutation: Insertion
• Mutation details: A 147 bp N-terminal 3X Flag tag followed by a PreScission cleavage site and a 6X HIS tag was inserted into the first exon downstream of the ATG start site and an FRT flanked neo cassette was inserted in the nonconserved region of intron 1 via homologous recombination. (J:314308)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ago2 Mutation: 56 strains or lines available

References

• Original: J:314308 Schmolka N, et al., MicroRNA-146a controls functional plasticity in gammadelta T cells by targeting NOD1. Sci Immunol. 2018 May 4;3(23)
• All: 1 reference(s)