Ptpn11^tm1.1Ckq
Targeted Allele Detail

Summary

• Symbol: Ptpn11^tm1.1Ckq
• Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1.1, Cheng-Kui Qu
• MGI ID: MGI:7442630
• Synonyms: Ptpn11^E76K
• Gene: Ptpn11 Location: Chr5:121268596-121329460 bp, - strand Genetic Position: Chr5, 61.72 cM, cytoband F
• Alliance: Ptpn11^tm1.1Ckq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332221
• Parent Cell Line: D1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 3 was replaced with a floxed neo/STOP cassette and a modified exon 3 in which nucleotide substitution (GAA to AAA) results in the amino acid substitution of lysine for glutamic acid at position 76 (E76K), mimicking a mutation found in some childhood acute leukemia and juvenile myelomonocytic leukemia (JMML) patients. Cre-mediated recombination removed the floxed stop cassette. (J:332221)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn11 Mutation: 43 strains or lines available

References

• Original: J:332221 Yan Y, et al., Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis. Sci Rep. 2022 Dec 17;12(1):21832
• All: 1 reference(s)