Fto^tm1Fcw
Targeted Allele Detail

Summary

• Symbol: Fto^tm1Fcw
• Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1, Fengchao Wang
• MGI ID: MGI:7442521
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^tm1Fcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273800
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting mutation floxed exon 3. An FRT-flanked neomycin resistance cassette was inserted into intron 4. (J:273800)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 76 strains or lines available

References

• Original: J:273800 Peng S, et al., Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med. 2019 Apr 17;11(488)
• All: 1 reference(s)