Fbxo11^{tm2c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Fbxo11^{tm2c(EUCOMM)Wtsi}
• Name: F-box protein 11; targeted mutation 2c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7442471
• Synonyms: FBXO11^fl
• Gene: Fbxo11 Location: Chr17:88298287-88372719 bp, - strand Genetic Position: Chr17, 57.87 cM
• Alliance: Fbxo11^{tm2c(EUCOMM)Wtsi} page
• IMPC: Fbxo11 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333407
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt1 cassette was inserted at position 88321613 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 88322400. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:333407)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxo11 Mutation: 54 strains or lines available

References

• Original: J:333407 Pighi C, et al., Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma. Blood Adv. 2021 Dec 14;5(23):5239-5257
• All: 1 reference(s)