Otoa^{em1(rtTA)Thore}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Otoa^{em1(rtTA)Thore}
• Name: otoancorin; endonuclease-mediated mutation 1, Wallace Thoreson
• MGI ID: MGI:7441916
• Synonyms: Otoa-rtTA
• Gene: Otoa Location: Chr7:120682647-120762316 bp, + strand Genetic Position: Chr7, 65.07 cM
• Alliance: Otoa^{em1(rtTA)Thore} page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Transactivator)
• Mutation: Insertion
• Mutation details: Using CRISPR/Cas9-directed genome editing, rtTA-polyA cassette was inserted into the first coding exon of the Otoa gene. (J:263636)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otoa Mutation: 57 strains or lines available

References

• Original: J:263636 Quadros RM, et al., Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins. Genome Biol. 2017 May 17;18(1):92
• All: 1 reference(s)