Rras2^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Rras2^tm1.1Geno
• Name: RAS oncogene related 2; targeted mutation 1.1, Genoway
• MGI ID: MGI:7439826
• Synonyms: Rras2(Q72L)^fl
• Gene: Rras2 Location: Chr7:113646017-113717016 bp, - strand Genetic Position: Chr7, 59.29 cM, cytoband F2
• Alliance: Rras2^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324845
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A cassette containing the following elements replaced exon 3: a lox511 site, wild-type exon 3, FRT-flanked neomycin resistance gene, loxP site, exon 3 containing a glutamine to leucine substitution at amino acid 72 (Q72L) in opposite orientation, lox511 site, and loxP site. The neomycin resistance gene was removed via flp-mediated recombination. Upon expression of cre recombinase, the wild-type exon 3 will be removed and the mutated exon harboring the Q72L missense mutation will be inserted in the forward orientation. (J:324845)

Tumor Data

List all tumor models in MMHCdb carrying Rras2^tm1.1Geno

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rras2 Mutation: 33 strains or lines available

References

• Original: J:324845 Fernandez-Pisonero I, et al., A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors. Cell Rep. 2022 Mar 15;38(11):110522
• All: 2 reference(s)