Ncor1^em2Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ncor1^em2Tcp
• Name: nuclear receptor co-repressor 1; endonuclease-mediated mutation 2, The Centre for Phenogenomics
• MGI ID: MGI:7439336
• Gene: Ncor1 Location: Chr11:62207132-62348200 bp, - strand Genetic Position: Chr11, 38.08 cM, cytoband B2
• Alliance: Ncor1^em2Tcp page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  This allele was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with a guide RNA with the spacer sequence TACTTCATCATGCGCCTTGC and a single-strand oligonucleotide. Subsequent NHEJ-mediated repair introduced a 45-bp deletion from Chr11:62294274 to 62294318 (GRCm39). The repair template was not integrated. This mutation is predicted to cause an in-frame deletion of 5 amino-acids and potentially of the splice acceptor site of the terminal exon (ENSMUSE00000589508) of ENSMUST00000069456.10. (J:200814)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncor1 Mutation: 396 strains or lines available

References

• Original: J:200814 Toronto Centre for Phenogenomics, Strains and alleles submitted by Toronto Centre for Phenogenomics (NorCOMM2, funded by Genome Canada and Ontario Genomics Institute OGI-051). MGI Direct Data Submission. 2013
• All: 1 reference(s)