Sox7^tm1.1Inki
Targeted Allele Detail

Summary

• Symbol: Sox7^tm1.1Inki
• Name: SRY (sex determining region Y)-box 7; targeted mutation 1.1, Injune Kim
• MGI ID: MGI:7438003
• Synonyms: Sox7^mCh
• Gene: Sox7 Location: Chr14:64181155-64188181 bp, + strand Genetic Position: Chr14, 33.34 cM, cytoband C3
• Alliance: Sox7^tm1.1Inki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251608
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic locus, spanning protein-coding sequences scattered in two neighboring exons and an intercalated intron, was replaced by the mCherry coding sequence and an FRT-flanked neomycin selection cassette. The neomycin selection cassette was removed via flp-mediated recombination. Homozygous mice show absence of transcript. (J:251608)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox7 Mutation: 19 strains or lines available

References

• Original: J:251608 Kim K, et al., SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling. Circ Res. 2016 Sep 16;119(7):839-52
• All: 2 reference(s)