Pycard^tm1Lix
Targeted Allele Detail

Summary

• Symbol: Pycard^tm1Lix
• Name: PYD and CARD domain containing; targeted mutation 1, Xiaoxia Li
• MGI ID: MGI:7437918
• Synonyms: Asc^flox
• Gene: Pycard Location: Chr7:127590545-127593039 bp, - strand Genetic Position: Chr7, 69.88 cM, cytoband F4
• Alliance: Pycard^tm1Lix page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258997
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The entire open reading frame (exons 1-3) was flanked by loxP sites. An FRT-flanked neomycin selection cassette was inserted downstream of the second loxP site. (J:258997)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pycard Mutation: 16 strains or lines available

References

• Original: J:258997 Martin BN, et al., T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. Nat Immunol. 2016 May;17(5):583-92
• All: 3 reference(s)