Lifr^tm1.1Stw
Targeted Allele Detail

Summary

• Symbol: Lifr^tm1.1Stw
• Name: LIF receptor alpha; targeted mutation 1.1, Colin L Stewart
• MGI ID: MGI:7437637
• Synonyms: LifR^flx
• Gene: Lifr Location: Chr15:7120095-7226970 bp, + strand Genetic Position: Chr15, 3.46 cM
• Alliance: Lifr^tm1.1Stw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245455
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A floxed hygro cassette was inserted upstream of exon 2 and a floxed neo cassette was inserted in the intron after exon 14. Successfully recombined ES cell clones were subjected to transient expression of Cre recombinase by transfection of pMC1-Cre. The resulting clone 18 with exons 2 to 14 floxed was used for the germline transmission. (J:245455)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lifr Mutation: 59 strains or lines available

References

• Original: J:245455 Cheng J, et al., Tissue-Specific Ablation of the LIF Receptor in the Murine Uterine Epithelium Results in Implantation Failure. Endocrinology. 2017 Jun 01;158(6):1916-1928
• All: 1 reference(s)