Sv2a^tm1.1Rogb
Targeted Allele Detail

Summary

• Symbol: Sv2a^tm1.1Rogb
• Name: synaptic vesicle glycoprotein 2a; targeted mutation 1.1, Bernard Rogister
• MGI ID: MGI:7437624
• Synonyms: SV2A^lox
• Gene: Sv2a Location: Chr3:96088543-96102499 bp, + strand Genetic Position: Chr3, 41.65 cM, cytoband F2
• Alliance: Sv2a^tm1.1Rogb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254886
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 3. The neomycin selection cassette was removed via flp-mediated recombination leaving exon 3 floxed. (J:254886)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sv2a Mutation: 37 strains or lines available

References

• Original: J:254886 Menten-Dedoyart C, et al., Development and Validation of a New Mouse Model to Investigate the Role of SV2A in Epilepsy. PLoS One. 2016;11(11):e0166525
• All: 3 reference(s)