Dlg4^tm2.1Mzlin
Targeted Allele Detail

Summary

• Symbol: Dlg4^tm2.1Mzlin
• Name: discs large MAGUK scaffold protein 4; targeted mutation 2.1 Michael Lin
• MGI ID: MGI:7437507
• Synonyms: PSD95-SMASh
• Gene: Dlg4 Location: Chr11:69908029-69938107 bp, + strand Genetic Position: Chr11, 42.96 cM, cytoband B4
• Alliance: Dlg4^tm2.1Mzlin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to replace the endogenous STOP codon of the gene with a SMASh cassette with a STOP codon, and a loxP-flanked neomycin (neo) cassette. The SMASh (Small Molecule-Assisted Shutoff) cassette contains a cis-cleaving hepatitis C virus (HCV) NS3 protease. Cre-mediated recombination removed the neo cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlg4 Mutation: 52 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)