Cd163^tm1.1Bakk
Targeted Allele Detail

Summary

• Symbol: Cd163^tm1.1Bakk
• Name: CD163 antigen; targeted mutation 1.1, Katarzyna Barczyk-Kahlert
• MGI ID: MGI:7435355
• Gene: Cd163 Location: Chr6:124281615-124307486 bp, + strand Genetic Position: Chr6, 59.13 cM, cytoband F2
• Alliance: Cd163^tm1.1Bakk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316783
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129 x C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and neo cassette were inserted upstream of exon 1 and a second loxP site was inserted downstream of exon 1 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 1. (J:316783)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd163 Mutation: 72 strains or lines available

Notes

ES cells = CV19

References

• Original: J:316783 Fischer-Riepe L, et al., CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow. J Allergy Clin Immunol. 2020 Nov;146(5):1137-1151
• All: 1 reference(s)