Crls1^tm1.1Tkato
Targeted Allele Detail

Summary

• Symbol: Crls1^tm1.1Tkato
• Name: cardiolipin synthase 1; targeted mutation 1.1, Tadafumi Kato
• MGI ID: MGI:7435167
• Synonyms: Crls1^flox
• Gene: Crls1 Location: Chr2:132688586-132708705 bp, + strand Genetic Position: Chr2, 64.77 cM, cytoband F3
• Alliance: Crls1^tm1.1Tkato page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300052
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exons 4 through 6. Flp-mediated recombination removed the selection cassette. (J:300052)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crls1 Mutation: 15 strains or lines available

References

• Original: J:300052 Kasahara T, et al., Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals. FASEB J. 2020 Jan;34(1):1465-1480
• All: 1 reference(s)