Junb^tm1.1Hsum
Targeted Allele Detail

Summary

• Symbol: Junb^tm1.1Hsum
• Name: jun B proto-oncogene, AP-1 transcription factor subunit; targeted mutation 1.1, Hideki Sumimoto
• MGI ID: MGI:7433003
• Synonyms: Junb^f
• Gene: Junb Location: Chr8:85703538-85705377 bp, - strand Genetic Position: Chr8, 41.41 cM, cytoband C2-D1
• Alliance: Junb^tm1.1Hsum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287427
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The single exon was replaced with a loxP-flanked Junb exon and an FRT-flanked pgk-neomycin cassette. The neomycin resistance cassette was removed via flp-mediated recombination, leaving the entire open reading frame floxed. (J:287427)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Junb Mutation: 21 strains or lines available

References

• Original: J:287427 Yamazaki S, et al., The AP-1 transcription factor JunB is required for Th17 cell differentiation. Sci Rep. 2017 Dec 12;7(1):17402
• All: 2 reference(s)