Ifrd1^tm1.1Ehin
Targeted Allele Detail

Summary

• Symbol: Ifrd1^tm1.1Ehin
• Name: interferon-related developmental regulator 1; targeted mutation 1.1, Eiichi Hinoi
• MGI ID: MGI:7432974
• Synonyms: Ifrd1^fl
• Gene: Ifrd1 Location: Chr12:40253128-40273184 bp, - strand Genetic Position: Chr12, 18.06 cM
• Alliance: Ifrd1^tm1.1Ehin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287473
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked neomycin resistance gene cassette was inserted upstream of exon 2 and a second loxP site was inserted downstream of exon 3. The neomycin gene was removed via flp-mediated recombination leaving exons 2-3 floxed. (J:287473)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifrd1 Mutation: 30 strains or lines available

References

• Original: J:287473 Iezaki T, et al., The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption. J Bone Miner Res. 2016 Mar;31(3):573-84
• All: 1 reference(s)