Kmt2a^tm1.1Afst
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm1.1Afst
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1.1, A Francis Stewart
• MGI ID: MGI:7432871
• Synonyms: Mll1^F
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm1.1Afst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317396
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A 6.7 kb lacZ cassette flanked by FRT sites was inserted into intron 1 of the Mll1 locus and additional loxP site was inserted downstream of exon 2. Flpe mediated recombination removed the reporter cassette leaving exon 2 floxed. (J:317396)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 137 strains or lines available

References

• Original: J:317396 Goveas N, et al., MLL1 is required for maintenance of intestinal stem cells. PLoS Genet. 2021 Dec;17(12):e1009250
• All: 1 reference(s)