Lonp1^tm1.2Pinm
Targeted Allele Detail

Summary

• Symbol: Lonp1^tm1.2Pinm
• Name: lon peptidase 1, mitochondrial; targeted mutation 1.2, Marcello Pinti
• MGI ID: MGI:7432865
• Gene: Lonp1 Location: Chr17:56921297-56933887 bp, - strand Genetic Position: Chr17, 29.42 cM, cytoband D
• Alliance: Lonp1^tm1.2Pinm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321165
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: In a step wise targeting process a floxed neo cassette was inserted downstream of exon 8. This was followed by removal of the neo leaving a single loxP site. Then an FRT flanked neo cassette and loxP site were inserted upstream of exon 5. Flp mediated recombination removed the neo leaving exons 5 -8 floxed. Finally, cre mediated recombination removed exons 5 - 8. (J:321165)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lonp1 Mutation: 40 strains or lines available

References

• Original: J:321165 De Gaetano A, et al., Impaired Mitochondrial Morphology and Functionality in Lonp1(wt/-) Mice. J Clin Med. 2020 Jun 8;9(6):1783
• All: 1 reference(s)