Nedd4l^tm1Toish
Targeted Allele Detail

Summary

• Symbol: Nedd4l^tm1Toish
• Name: neural precursor cell expressed, developmentally down-regulated gene 4-like; targeted mutation 1, Tomoaki Ishigami
• MGI ID: MGI:7432853
• Synonyms: Nedd4-2 C2-
• Gene: Nedd4l Location: Chr18:65020776-65350899 bp, + strand Genetic Position: Chr18, 37.57 cM, cytoband E1
• Alliance: Nedd4l^tm1Toish page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269894
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 (74 bp), encoding the C2 domain, was replaced with a pgk-neo cassette resulting in loss of the C2 isoform. (J:269894)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nedd4l Mutation: 75 strains or lines available

References

• Original: J:269894 Minegishi S, et al., An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice. Sci Rep. 2016 Jun 3;6:27137
• All: 2 reference(s)