Tac1^em1(flp)Pc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tac1^em1(flp)Pc
• Name: tachykinin 1; endonuclease-mediated mutation 1, Peng Cao
• MGI ID: MGI:7432814
• Synonyms: Tac1-IRES-Flp
• Gene: Tac1 Location: Chr6:7555061-7562978 bp, + strand Genetic Position: Chr6, 3.31 cM
• Alliance: Tac1^em1(flp)Pc page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Tac1^em1(flp)Pc expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tac1 (MGI:98474)

• Using the CRISPR/Cas9 system, the IRES-Flpe sequence was inserted into the end of the Tac1 gene. (J:333065)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tac1 (mouse) Summary of all recombinase alleles driven by Tac1. Comparative matrix view of recombinase activities Alliance mouse Tac1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tac1 Mutation: 36 strains or lines available

References

• Original: J:333065 Xie Z, et al., The gut-to-brain axis for toxin-induced defensive responses. Cell. 2022 Nov 10;185(23):4298-4316.e21
• All: 1 reference(s)