Gt(ROSA)26Sor^{em3(Gsdmd*)Cya}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em3(Gsdmd*)Cya}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 3, Cyagen Biosciences
• MGI ID: MGI:7432801
• Synonyms: GSDMD-N^LSL
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em3(Gsdmd*)Cya} page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Using CRISPR-CAS9 technology, 3Flag-GSDMD-N fragment with LoxP-flanked stop cassette was inserted into the Gt(ROSA)26Sor locus. (J:333061)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1042 strains or lines available

References

• Original: J:333061 Hu Y, et al., The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2210809119
• All: 1 reference(s)