Hmgcs2^em1Arima
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hmgcs2^em1Arima
• Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2; endonuclease-mediated mutation 1, Yuichiro Arima
• MGI ID: MGI:7432780
• Synonyms: Hmgcs2-floxed
• Gene: Hmgcs2 Location: Chr3:98187751-98218054 bp, + strand Genetic Position: Chr3, 42.74 cM
• Alliance: Hmgcs2^em1Arima page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Using the CRISPRCas9 system, exon 2 of the Hmgcs2 gene was flanked by the loxP sequences. (J:333060)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgcs2 Mutation: 33 strains or lines available

References

• Original: J:333060 Arima Y, et al., Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation. Nat Metab. 2021 Feb;3(2):196-210
• All: 2 reference(s)