Susd2^em1Hwen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Susd2^em1Hwen
• Name: sushi domain containing 2; endonuclease-mediated mutation 1, Haitao Wen
• MGI ID: MGI:7432659
• Synonyms: Susd2^-
• Gene: Susd2 Location: Chr10:75472540-75479842 bp, - strand Genetic Position: Chr10, 38.56 cM, cytoband B5.3
• Alliance: Susd2^em1Hwen page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using a CRISPR/Cas9-mediated genome engineering strategy, the exon 1-14 of the Susd2 gene was deleted. (J:333048)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Susd2 Mutation: 39 strains or lines available

References

• Original: J:333048 Zhao B, et al., SUSD2 suppresses CD8(+) T cell antitumor immunity by targeting IL-2 receptor signaling. Nat Immunol. 2022 Nov;23(11):1588-1599
• All: 1 reference(s)