Gt(ROSA)26Sor^{tm1.1(CAG-Nfatc*,-tdTomato)Znlab}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(CAG-Nfatc*,-tdTomato)Znlab}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Ivan Zanoni
• MGI ID: MGI:7432376
• Synonyms: iNFATuation
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(CAG-Nfatc*,-tdTomato)Znlab} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321772
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct contains from 3'; to 5': a loxP-lox2272-CAG (in reverse orientation)-loxP-FRT-lox272-VIVIT peptide (MAGPHPVIVITGPHEE)-IRES-tdTomato-pA. An FRT-flanked neomycin cassette is a part of the construct. Flp-mediated recombination removed the neomycin cassette. (J:321772)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 945 strains or lines available

References

• Original: J:321772 Poli V, et al., Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia. Immunity. 2022 Feb 8;55(2):224-236.e5
• All: 1 reference(s)