Ptpn1^em1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptpn1^em1Nju
• Name: protein tyrosine phosphatase, non-receptor type 1; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:7432326
• Synonyms: Ptpn1-KO
• Gene: Ptpn1 Location: Chr2:167773977-167821305 bp, + strand Genetic Position: Chr2, 87.99 cM, cytoband H3
• Alliance: Ptpn1^em1Nju page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using the CRISPR/Cas9 System, the exons 2-8 of the Ptpn1 gene were deleted to induces a frameshift mutation. (J:296768)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn1 Mutation: 36 strains or lines available

References

• Original: J:296768 Xu X, et al., Inhibition of PTP1B Promotes M2 Polarization via MicroRNA-26a/MKP1 Signaling Pathway in Murine Macrophages. Front Immunol. 2019;10:1930
• All: 2 reference(s)