Ect2lem1(IMPC)J
Endonuclease-mediated Allele Detail
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Symbol: |
Ect2lem1(IMPC)J |
Name: |
epithelial cell transforming sequence 2 oncogene-like; endonuclease-mediated mutation 1, Jackson |
MGI ID: |
MGI:7432300 |
Gene: |
Ect2l Location: Chr10:18004651-18086638 bp, - strand Genetic Position: Chr10, 7.47 cM
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Alliance: |
Ect2lem1(IMPC)J page
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IMPC: |
Ect2l gene page |
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Strain of Origin: |
C57BL/6NJ
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Project Collection: |
IMPC
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GTACCAGGAAAAGGCTTAAA and GCTGGGTAAGTGTCTCAAGG, which resulted in a 499 bp deletion beginning at Chromosome 10 position 18,173,871 bp and ending after 18,174,369 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000615953 (exon 4) and 246 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 126 and early truncation 10amino acids later. There is a 4 bp insertion at the deletion site (TGAA).
(J:188991)
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Inheritance: |
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Not Specified |
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Original: |
J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012; |
All: |
1 reference(s) |
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