Kmt2a^tm4(AFF1)Thr
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm4(AFF1)Thr
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 4, Terence H Rabbitts
• MGI ID: MGI:7432286
• Synonyms: Mll-AF4 lox66/71
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm4(AFF1)Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241130
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a lox66 site, neomycin resistance cassette, polyadenylation sequence, inverted human cDNA, polyadenylation sequence, intron, and lox71 site into exon 10. (J:241130)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:241130 Metzler M, et al., A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology. Oncogene. 2006 May 25;25(22):3093-103
• All: 1 reference(s)