Vav1tm1.1(Myo1f)Tpal
Targeted Allele Detail
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Symbol: |
Vav1tm1.1(Myo1f)Tpal |
Name: |
vav 1 oncogene; targeted mutation 1.1, Teresa Palomero |
MGI ID: |
MGI:7431424 |
Synonyms: |
Vav1co-Vav1-Myo1f |
Gene: |
Vav1 Location: Chr17:57586100-57635031 bp, + strand Genetic Position: Chr17, 29.76 cM
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Alliance: |
Vav1tm1.1(Myo1f)Tpal page
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Germline Transmission: |
Earliest citation of germline transmission:
J:325006
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence) |
Mutation: |
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Insertion
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Vav1tm1.1(Myo1f)Tpal expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Myo1f (MGI:107711) |
Results in expression of a Vav1/Myo1 oncogenic fusion. |
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Mutation details: A minigene containing floxed Vav1 exon 25-27 and FRT-flanked neomycin selection cassette were introduced in intron 24 and the downstream exons 25 and 26 were replaced with Vav1 exons 25-27 fused to the cDNA sequence corresponding to exons 25-28 of Myo1f. Exon 24 of Vav1 is spliced into the exon 25-27 minigene resulting in expression of a wild-type Vav1 mRNA. The neomycin cassette was removed via flp-mediated recombination. Cre recombinase expression is needed to remove the floxed exon 25-27 minigene to lead to exon 24 being spliced into the Vav1 exon 25-27Myo1f exons 25-28 minigene, which will result in the expression of the Vav1-Myo1f oncogenic fusion.
(J:325006)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Vav1 Mutation: |
59 strains or lines available
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Original: |
J:325006 Cortes JR, et al., Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma. Cell Rep. 2022 Apr 19;39(3):110695 |
All: |
1 reference(s) |
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