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Vav1tm1.1(Myo1f)Tpal
Targeted Allele Detail
Summary
Symbol: Vav1tm1.1(Myo1f)Tpal
Name: vav 1 oncogene; targeted mutation 1.1, Teresa Palomero
MGI ID: MGI:7431424
Synonyms: Vav1co-Vav1-Myo1f
Gene: Vav1  Location: Chr17:57586100-57635031 bp, + strand  Genetic Position: Chr17, 29.76 cM
Alliance: Vav1tm1.1(Myo1f)Tpal page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:325006
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Vav1tm1.1(Myo1f)Tpal expresses 1 gene
 
Mutation detailsA minigene containing floxed Vav1 exon 25-27 and FRT-flanked neomycin selection cassette were introduced in intron 24 and the downstream exons 25 and 26 were replaced with Vav1 exons 25-27 fused to the cDNA sequence corresponding to exons 25-28 of Myo1f. Exon 24 of Vav1 is spliced into the exon 25-27 minigene resulting in expression of a wild-type Vav1 mRNA. The neomycin cassette was removed via flp-mediated recombination. Cre recombinase expression is needed to remove the floxed exon 25-27 minigene to lead to exon 24 being spliced into the Vav1 exon 25-27Myo1f exons 25-28 minigene, which will result in the expression of the Vav1-Myo1f oncogenic fusion. (J:325006)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vav1 Mutation:  59 strains or lines available
References
Original:  J:325006 Cortes JR, et al., Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma. Cell Rep. 2022 Apr 19;39(3):110695
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory