Foxo1^tm3.1Dac
Targeted Allele Detail

Summary

• Symbol: Foxo1^tm3.1Dac
• Name: forkhead box O1; targeted mutation 3.1, Domenico Accili
• MGI ID: MGI:7431423
• Synonyms: Foxo1^dbd
• Gene: Foxo1 Location: Chr3:52175758-52257530 bp, + strand Genetic Position: Chr3, 23.19 cM
• Alliance: Foxo1^tm3.1Dac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252119
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Through homologous recombination by recombinase-mediated cassette exchange, the Foxo1 gene of residues necessary for DNA binding are mutated (N208A, H212R, K219R). (J:252119)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxo1 Mutation: 34 strains or lines available

References

• Original: J:252119 Cook JR, et al., A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism. Diabetes. 2015 Jun;64(6):1951-65
• All: 2 reference(s)