Metrnl^tm1.1Cymi
Targeted Allele Detail

Summary

• Symbol: Metrnl^tm1.1Cymi
• Name: meteorin, glial cell differentiation regulator-like; targeted mutation 1.1, Chao-Yu Miao
• MGI ID: MGI:7431408
• Synonyms: Metrnl^loxP
• Gene: Metrnl Location: Chr11:121592370-121607132 bp, + strand Genetic Position: Chr11, 86.89 cM
• Alliance: Metrnl^tm1.1Cymi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246868
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector was constructed by inserting LoxP sites flanking exon 3 and the coding region of exon 4 of the Metrnl gene with a neomycin cassette flanked by FRT sites. The neo cassette was removed by crossing to Flp mice. (J:246868)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Metrnl Mutation: 31 strains or lines available

References

• Original: J:246868 Li ZY, et al., Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARgamma Signaling. Diabetes. 2015 Dec;64(12):4011-22
• All: 3 reference(s)