Zfp423tm2Ggc
Targeted Allele Detail
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Symbol: |
Zfp423tm2Ggc |
Name: |
zinc finger protein 423; targeted mutation 2, Giacomo Consalez |
MGI ID: |
MGI:7431405 |
Synonyms: |
Zfp423 delta28-30 |
Gene: |
Zfp423 Location: Chr8:88388438-88686223 bp, - strand Genetic Position: Chr8, 42.29 cM, cytoband C4
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Alliance: |
Zfp423tm2Ggc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:245759
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A cassette of the sequence corresponding to the exons 6 and 7 of the Zf423 gene with the nucleotides 3861-4108 of the ORF deleted and an FRT flanked neomycin selection cassette replaced the endogenous exons 6 and 7. It causes a frameshift mutation that produces a stop codon 158 bp into exon 8. The resulting C-termally trancated protein lacks zinc fingers 28-30 and 91 C-terminal amino acids.
(J:245759)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Zfp423 Mutation: |
274 strains or lines available
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Original: |
J:245759 Casoni F, et al., Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors. Development. 2017 Oct 15;144(20):3686-3697 |
All: |
2 reference(s) |
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