Krt8^tm1.1Toiv
Targeted Allele Detail

Summary

• Symbol: Krt8^tm1.1Toiv
• Name: keratin 8; targeted mutation 1.1, Diana M Toivola
• MGI ID: MGI:7431245
• Synonyms: K8^flox
• Gene: Krt8 Location: Chr15:101905146-101912777 bp, - strand Genetic Position: Chr15, 57.2 cM
• Alliance: Krt8^tm1.1Toiv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332898
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The exon 3 is flanked with loxP sites and a neomycin selection segment flanked with FRT sites were inserted into the Krt8 gene. The neomycin segment was then removed using flp recombinase, leaving the loxP sites intact flanking exon 3. (J:332898)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt8 Mutation: 30 strains or lines available

References

• Original: J:332898 Stenvall CA, et al., Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon. Cell Mol Life Sci. 2021 Dec 24;79(1):10
• All: 4 reference(s)