Ldha^tm1.1Pse
Targeted Allele Detail

Summary

• Symbol: Ldha^tm1.1Pse
• Name: lactate dehydrogenase A; targeted mutation 1.1, Pankaj Seth
• MGI ID: MGI:7431242
• Synonyms: LDH^fl
• Gene: Ldha Location: Chr7:46491698-46505051 bp, + strand Genetic Position: Chr7, 30.6 cM
• Alliance: Ldha^tm1.1Pse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214778
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted upstream of exon 2 a FRT-flanked beta-geo cassette and loxP site. A second loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the reporter/selection cassette. (J:214778)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldha Mutation: 34 strains or lines available

References

• Original: J:214778 Xie H, et al., Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. Cell Metab. 2014 May 6;19(5):795-809
• All: 3 reference(s)