Tg(RP23-425D18)deltaUHRsnk
Transgene Detail

Summary

• Symbol: Tg(RP23-425D18)deltaUHRsnk
• Name: transgene insertion deltaUH, James Resnick
• MGI ID: MGI:7430965
• Synonyms: 425deltaU1-U3H
• Transgene: Tg(RP23-425D18)deltaUHRsnk Location: unknown
• Alliance: Tg(RP23-425D18)deltaUHRsnk page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The insertion comprises mouse BAC RP23-425D18 where the sequence from the 3' end of exon 5 through the 5' end of exon 7 of Snrpn and upstream exons U1, U2, and U3 were deleted. The BAC contains the entire Snrpn gene plus 70 kb downstream and 100 kb upstream sequence, which includes six Snrpn upstream exons (U1, U2, U3, alpha, beta, gamma). This allele, which has a single copy integrated, retained the endogenous imprinting profile of the Snrpn DMR, probably owing to the site of integration, since identical sister allele Tg(RP23-425D18)deltaUDRsnk lost imprinting. (J:332846)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:332846 Smith EY, et al., Transcription is required to establish maternal imprinting at the Prader-Willi syndrome and Angelman syndrome locus. PLoS Genet. 2011 Dec;7(12):e1002422
• All: 1 reference(s)