Gt(ROSA)26Sor^{tm1(Sharpin)Kiwa}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Sharpin)Kiwa}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Kazuhiro Iwai
• MGI ID: MGI:7430903
• Synonyms: R26-Sharpin, Rosa26-Sharpin-ires-Egfp
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Sharpin)Kiwa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279330
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted into the locus the mouse sequence fused to an N-terminal FLAG-His tag and FRT-flanked IRES, EGFP reporter gene, and polyadenylation sequence. A floxed neomycin resistance and STOP cassette was placed upstream of the expression cassette. (J:279330)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:279330 Sasaki K, et al., Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death. Nat Commun. 2019 Aug 28;10(1):3878
• All: 1 reference(s)