Sost^tm1.1Ozg
Targeted Allele Detail

Summary

• Symbol: Sost^tm1.1Ozg
• Name: sclerostin; targeted mutation 1.1, Ozgene
• MGI ID: MGI:7430798
• Synonyms: Sost^flox
• Gene: Sost Location: Chr11:101853284-101857841 bp, - strand Genetic Position: Chr11, 65.48 cM, cytoband D
• Alliance: Sost^tm1.1Ozg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332799
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The loxP sites flank the exon 1 of the murine Sost (sclerostin) gene without disrupting splicing or regulatory sequences. The FLPe recombinase removed the neomycin selection cassette. (J:332799)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sost Mutation: 34 strains or lines available

References

• Original: J:332799 O'Donohue AK, et al., Targeted postnatal knockout of Sclerostin using a bone-targeted adeno-associated viral vector increases bone anabolism and decreases canalicular density. Bone. 2022 Nov 30;167:116636
• All: 1 reference(s)