Gpr119^em1Ikim
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gpr119^em1Ikim
• Name: G-protein coupled receptor 119; endonuclease-mediated mutation 1, Ikuo Kimura
• MGI ID: MGI:7429201
• Synonyms: Gpr119 KO
• Gene: Gpr119 Location: ChrX:47756856-47763355 bp, - strand Genetic Position: ChrX, 25.69 cM
• Alliance: Gpr119^em1Ikim page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using the CRISPR-Cas9 genome editing system the protein-coding sequence (CDS) of GPR119 was deleted. Four male mice (KO1-4) were obtained. The confirmed sequence of the one line (KO1) with 1372-bp deletion around the target and full deletion of the CDS of GPR119. (J:332783)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr119 Mutation: 8 strains or lines available

References

• Original: J:332783 Igarashi M, et al., Intestinal GPR119 activation by microbiota-derived metabolites impacts feeding behavior and energy metabolism. Mol Metab. 2022 Nov 30;67:101649
• All: 1 reference(s)