Slc39a5^tm1.1Fudi
Targeted Allele Detail

Summary

• Symbol: Slc39a5^tm1.1Fudi
• Name: solute carrier family 39 (metal ion transporter), member 5; targeted mutation 1.1, Fudi Wang
• MGI ID: MGI:7428754
• Synonyms: Slc39a5^fl
• Gene: Slc39a5 Location: Chr10:128231800-128237098 bp, - strand Genetic Position: Chr10, 76.55 cM, cytoband D3
• Alliance: Slc39a5^tm1.1Fudi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279170
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked PGK-neomycin selection cassette and a loxP site were inserted upstream of exon 4 and a second loxP site was inserted downstream of exon 4. The neomycin selection cassette was removed via flp-mediated recombination leaving exon 4 floxed. (J:279170)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc39a5 Mutation: 28 strains or lines available

References

• Original: J:279170 Wang X, et al., The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic beta-cells via Sirt1- and Pgc-1alpha-mediated regulation of Glut2. Protein Cell. 2019 Jun;10(6):436-449
• All: 1 reference(s)