Slc39a10^tm1.1Fudi
Targeted Allele Detail

Summary

• Symbol: Slc39a10^tm1.1Fudi
• Name: solute carrier family 39 (zinc transporter), member 10; targeted mutation 1.1, Fudi Wang
• MGI ID: MGI:7428739
• Synonyms: Slc39a10^fl
• Gene: Slc39a10 Location: Chr1:46846704-46932012 bp, - strand Genetic Position: Chr1, 24.07 cM
• Alliance: Slc39a10^tm1.1Fudi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256512
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked PGK-neomycin selection cassette and loxP site were inserted upstream of exon 3 and a second loxP site was inserted downstream of exon 3. The neomycin selection cassette was removed via flp-mediated recombination leaving exon 3 floxed. (J:256512)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc39a10 Mutation: 49 strains or lines available

References

• Original: J:256512 Gao H, et al., Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12940-12945
• All: 1 reference(s)