Lat^em1Eagu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lat^em1Eagu
• Name: linker for activation of T cells; endonuclease-mediated mutation 1, Enrique Aguado
• MGI ID: MGI:7428662
• Synonyms: LAT^G135D
• Gene: Lat Location: Chr7:125962996-125968742 bp, - strand Genetic Position: Chr7, 69.01 cM
• Alliance: Lat^em1Eagu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 to convert the GGC codon found in exon 7 of the Lat gene and corresponding to the glycine residue present at position 135 of LAT into a GAC codon coding for an aspartic acid. p.G135D. (J:332689)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lat Mutation: 11 strains or lines available

References

• Original: J:332689 Arbulo-Echevarria MM, et al., Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation. Front Immunol. 2022;13:1054920
• All: 1 reference(s)