Trf^tm1.2Fudi
Targeted Allele Detail

Summary

• Symbol: Trf^tm1.2Fudi
• Name: transferrin; targeted mutation 1.2, Fudi Wang
• MGI ID: MGI:7428661
• Gene: Trf Location: Chr9:103086075-103107485 bp, - strand Genetic Position: Chr9, 55.03 cM, cytoband F1-F3
• Alliance: Trf^tm1.2Fudi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301391
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked PGK-neomcyin selection cassette and loxP site were inserted upstream of exon 4. A second loxP site was inserted downstream of exon 5. The neomycin selection gene was removed via flp-mediated recombination. Exons 4 and 5 were deleted via cre-mediated recombination in the germline. (J:301391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trf Mutation: 42 strains or lines available

References

• Original: J:301391 Yu Y, et al., Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood. 2020 Aug 6;136(6):726-739
• All: 1 reference(s)