Ttll7^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Ttll7^tm1.2Ics
• Name: tubulin tyrosine ligase-like family, member 7; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:7428563
• Gene: Ttll7 Location: Chr3:146558122-146689764 bp, + strand Genetic Position: Chr3, 72.28 cM, cytoband H3
• Alliance: Ttll7^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314456
• Parent Cell Line: BD10 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7 and a loxP site, FRT site, neomycin resistance cassette, loxP site, and second FRT site were inserted downstream of exon 7. The neomycin resistance cassette was removed via flp-mediated recombination. Exon 7 was deleted via cre-mediated recombination in the germline. (J:314456)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttll7 Mutation: 40 strains or lines available

References

• Original: J:314456 Bodakuntla S, et al., Distinct roles of alpha- and beta-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration. EMBO J. 2021 Jul 26;:e108498
• All: 1 reference(s)