Lhx1os^em1Ibo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lhx1os^em1Ibo
• Name: LIM homeobox 1, opposite strand; endonuclease-mediated mutation 1, Irene Bozzon
• MGI ID: MGI:7428532
• Synonyms: Lhx1os^-
• Gene: Lhx1os Location: Chr11:84416486-84426657 bp, + strand Genetic Position: Chr11, 51.31 cM
• Alliance: Lhx1os^em1Ibo page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR-Cas9 editing inserted a poly-A signal followed by two copies of the binding sites for the MAZ transcription factor which pause Pol II and promote termination in the second exon of the gene (J:332662)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx1os Mutation: 0 strains or lines available

References

• Original: J:332662 Pellegrini F, et al., A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment. iScience. 2023 Jan 20;26(1):105891
• All: 1 reference(s)